SLC Library (LPF101)

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Human CRISPRko library targeting solute carriers

Lentiviral ubiquitin-proteasome library
Category: SpCas9, genome-wide
Cat. no. LPF101 (human, 4 gRNAs/gene, 1 gRNA/plasmid, Puro)

Amount: 250ug

20,381 protein-coding genes (Ensembl release 109)
4 unique gRNAs/gene, assembled into 2 unique pairs
40,935 gRNA combinations

→ see below for more details

Category: CRISPR libraries

Explore Vivlion’s flagship genome-wide fixed-pair PRCISR™ CRISPR knockout gRNA library for lentiviral delivery.

Setting benchmarks in uniformity, efficiency and gene coverage.
Produced with Vivlion®’s proprietary 3Cs technology.

Comprehensive coverage: Targets 20,381 protein-coding genes, encompassing 99.8% of all ENSEMBL-identified genes (build 109).
Enhanced diversity: Features 40,935 gRNAs, with 4 gRNAs per gene arranged in 2 pairs to maximize editing efficiency.
Optimized activity: gRNAs meticulously selected for highest activity levels, ensuring robust performance.
Innovative quality control: Incorporates advanced screening quality control concepts for reliable results.
Expert support: Access data sheets and handling protocols tailored to streamline your research upon request.

Empower your genetic research with Vivlion’s advanced CRISPR solutions.
Achieve unparalleled precision and effectiveness in functional genomics.

Delivery format:	Plasmid DNA in buffer
Target genes:	20,381 of 20,421 protein-coding genes (Ensembl release 109)
Arrangement:	4 unique gRNAs per gene, assembled into 2 unique pairs
Size:	40,935 gRNA combinations
Controls:	LacZ (96) Luciferase (24) eGFP (22) Safe harbor: AAVS1 (42) and IL25 (22) DNA-damaged induced apoptosis: SuperCutter (4)
Provided vector:	1x P-0162 (Link to plasmid map)
gRNA promoters:	hU6 and h7SK
Cas9:	no
Selection antibiotics:	Puromycin

Optional:
Fluorescence:	mCherry

3Cs gRNA reagents and libraries are for R&D use only and not intended for human or animal diagnostic or therapeutic use, or other uses. The lentiviral transduction particles produced are replication incompetent and it is recommended they be treated as Bio-Safety Level 2 (BSL-2) organisms in laboratory handling. Follow all published BSL-2 guidelines for laboratory handling and waste decontamination.
This product is subject to third-party licenses and is sold under limited use label licenses from Broad Institute Inc. and ERS Genomics. By ordering these products, you accept the terms and conditions of all applicable Limited Use Label Licenses. Vivlion® cannot exclude that additional third-party rights exist. Link to limited use label licenses.

The client undertakes to use the purchased products exclusively for his own research purposes and not to resell them to third parties or to pass them on to third parties in any other form.

PDF of product sheet

Product certificate/QC

Gene list

Plasmid Map

Limited licenses